CCASE advocates for and engages in disparities research and evaluation that addresses the cultural, social, and structural determinants that reproduce inequity in behavioral health. We focus on stigma and discrimination, housing instability, carceral involvement, and substance use – each posing challenges that should be prioritized as we rethink our current systems of care. The determinants are complex as they intertwine with race, ethnicity, sexual identity, socioeconomic condition, immigration status, language barriers, and aging. Understanding the intersection of these multilevel constructs is essential, and at the forefront as we create and/or adapt the most innovative, scalable, and sustainable strategies for behavioral health service delivery.